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KMID : 0617219930040010023
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Duksung Bulletin Phamaceutical Sciences
1993 Volume.4 No. 1 p.23 ~ p.29
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Study on Polymorphism of Cimetidine
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Abstract
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Five crystalline forms of cimetidine, four anhydrous and a monohydrate, have been prepared, and their thermal behavriours have been studied by differential thermal analysis and thermo-gravimetry. The dissolution rates of the five forms were determined in distilled water at 37℃. The results showed a significant difference in the dissolution rate. Polymorphic transformation occurred spontaneously during storage at room condition and was accelerated by applied energy during formulation process-milling.
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